A-kinase-anchoring proteins
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چکیده
منابع مشابه
A-kinase-anchoring proteins.
Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation (Pawson and Nash, 2003). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-kinaseanchoring proteins (AKAPs). AKAPs provide a framework for the coordination of phosphorylation and ...
متن کاملA-kinase anchoring proteins take shape.
A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates. Recently the structural basis for these protein-protein interactions has been elucidated by x-ray crystallography. Recent reports have identified AKAPs...
متن کاملA-kinase anchoring proteins: protein kinase A and beyond.
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of t...
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The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of...
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This pathway proceeds from the membrane bound gua-nine nucleotide-binding protein Ras, through the se-Vollum Institute, Oregon Health Sciences University quential activation of the cytoplasmic serine/threonine Mail Code L474 kinases Raf, MAP-kinase kinase (MEK), and MAP kinase Portland Oregon, 97201–3098 (MAPK) and leads to specific gene expression in the nucleus. In the budding yeast S. cerevi...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2005
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.02416